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1

The Opioid Crisis and the Future of Addiction and Pain Therapeutics

Coussens, Nathan P., Sittampalam, G. Sitta, Jonson, Samantha G., Hall, Matthew D., Gorby, Heather E., Tamiz, Amir P., McManus, Owen B., Felder, Christian C., Rasmussen, Kurt

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2019

Language:

english

File:

PDF, 257 KB

english, 2019

2

Inhale, exhale: Probing the inside-out mechanism of nicotine addiction using novel fluorescent sensors

McManus, Owen B., Werley, Christopher A., Dempsey, Graham T.

Journal:

The Journal of General Physiology

Year:

2019

Language:

english

File:

PDF, 697 KB

english, 2019

3

Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels

Qu, Chunrong, Ding, Mingmin, Zhu, Yingmin, Lu, Yungang, Du, Juan, Miller, Melissa, Tian, Jinbin, Zhu, Jinmei, Xu, Jian, Wen, Meng, Er-Bu, AGA, Wang, Jule, Xiao, Yuling, Wu, Meng, McManus, Owen B., Li,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.93 MB

english, 2017

4

Towards Carbon-Neutral CO 2 Conversion to Hydrocarbons

Mattia, Davide, Jones, Matthew D., O'Byrne, Justin P., Griffiths, Owen G., Owen, Rhodri E., Sackville, Emma, McManus, Marcelle, Plucinski, Pawel

Journal:

Year:

2015

Language:

english

File:

PDF, 2.26 MB

english, 2015

5

Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology

Williams, Luis A., Joshi, Vaibhav, Murphy, Michael, Ferrante, John, Werley, Christopher A., Brookings, Theodore, McManus, Owen, Grosse, Johannes, Davies, Ceri H., Dempsey, Graham T.

Journal:

Neurochemical Research

Year:

2019

Language:

english

File:

PDF, 3.08 MB

english, 2019

6

Inhale, exhale: Probing the inside-out mechanism of nicotine addiction using novel fluorescent sensors

McManus, Owen B., Werley, Christopher A., Dempsey, Graham T.

Journal:

The Journal of General Physiology

Year:

2019

File:

PDF, 697 KB

2019

7

Calcium-activated potassium channels: Regulation by calcium

Owen B. McManus

Journal:

Journal of Bioenergetics and Biomembranes

Year:

1991

Language:

english

File:

PDF, 1.40 MB

english, 1991

8

High-conductance calcium-activated potassium channels; Structure, pharmacology, and function

Gregory J. Kaczorowski, Hans -Günther Knaus, Reid J. Leonard, Owen B. McManus, Maria L. Garcia

Journal:

Journal of Bioenergetics and Biomembranes

Year:

1996

Language:

english

File:

PDF, 1.36 MB

english, 1996

9

Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic β-cells

James Herrington, Manuel Sanchez, Denize Wunderler, Lizhen Yan, Randal M. Bugianesi, Ivy E. Dick, Sam A. Clark, Richard M. Brochu, Birgit T. Priest, Martin G. Kohler, Owen B. McManus

Journal:

The Journal of Physiology

Year:

2005

Language:

english

File:

PDF, 535 KB

english, 2005

10

Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels

Knaus, Hans-Guenther, McManus, Owen B., Lee, Seok H., Schmalhofer, William A., Garcia-Calvo, Margarita, Helms, Lisa M. H., Sanchez, Manuel, Giangiacomo, Kathleen, Reuben, John P.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.73 MB

english, 1994

11

Role of the C-Terminus of the High-Conductance Calcium-Activated Potassium Channel in Channel Structure and Function

Dai, Ge, Schmalhofer, William A., Sanchez, Manuel, Dewan, Ashvin, Secades, Lorena, Hanner, Markus, Knaus, Hans-Guenther, McManus, Owen B., Kohler, Martin, Kaczorowski, Gregory J.

Journal:

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

12

Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels

Giangiacomo, Kathleen M., Sugg, Elizabeth E., Garcia-Calvo, Margarita, Leonard, Reid J., McManus, Owen B., Kaczorowski, Gregory J., Garcia, Maria L.

Journal:

Year:

1993

Language:

english

File:

PDF, 1004 KB

english, 1993

13

Correolide and Derivatives Are Novel Immunosuppressants Blocking the Lymphocyte Kv1.3 Potassium Channels

Gloria C. Koo, Joseph T. Blake, Kashmira Shah, Mary Jo Staruch, Francis Dumont, Denise Wunderler, Manuel Sanchez, Owen B. McManus, Anna Sirotina-Meisher, Paul Fischer, Robert C. Boltz, Michael A. Goet

Journal:

Cellular Immunology

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

14

Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

Gary C. Davis, Yali Kong, Mikell Paige, Zhang Li, Ellen C. Merrick, Todd Hansen, Simeng Suy, Kan Wang, Sivanesan Dakshanamurthy, Antoinette Cordova, Owen B. McManus, Brande S. Williams, Maksymilian Ch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 627 KB

english, 2012

15

Cerebral palsy registries

Christine Cans, Geraldine Surman, Vicki McManus, David Coghlan, Owen Hensey, Ann Johnson

Journal:

Seminars in Pediatric Neurology

Year:

2004

Language:

english

File:

PDF, 57 KB

english, 2004

16

Functional role of the β subunit of high conductance calcium-activated potassium channels

Owen B McManus, Lisa M.H Helms, Leo Pallanck, Barry Ganetzky, Richard Swanson, Reid J Leonard

Journal:

Year:

1995

Language:

english

File:

PDF, 545 KB

english, 1995

17

Trace metal enrichments in Lake Tanganyika sediments: Controls on trace metal burial in lacustrine systems

Rebecca Poulson Brucker, James McManus, Silke Severmann, Jeremy Owens, Timothy W. Lyons

Journal:

Geochimica et Cosmochimica Acta

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

18

Complement reduces virus replication and myocardial injury in acute Coxsackie virus B3-induced myocarditis

Bobby Yanagawa, Caroline Cheung, Bruce McManus, Decheng Yang, Owen Spiller

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 88 KB

english, 2008

19

Identification of a New Class of Inhibitors of the Voltage-Gated Potassium Channel, K v 1.3, with Immunosuppressant Properties †

Schmalhofer, William A., Bao, Jianming, McManus, Owen B., Green, Brian, Matyskiela, Mary, Wunderler, Denise, Bugianesi, Randal M., Felix, John P., Hanner, Markus, Linde-Arias, Ana-Rosa, Ponte, Cristia

Journal:

Year:

2002

Language:

english

File:

PDF, 291 KB

english, 2002

20

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective Kv7.1 (KCNQ1) potassium channel activator

Mattmann, Margrith E., Yu, Haibo, Lin, Zhihong, Xu, Kaiping, Huang, Xiaofang, Long, Shunyou, Wu, Meng, McManus, Owen B., Engers, Darren W., Le, Uyen M., Li, Min, Lindsley, Craig W., Hopkins, Corey R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 5.23 MB

english, 2012

21

Discovery of a Series of 2-Phenyl- N -(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of K v 7.2 (KCNQ2) Channel Pharmacology: Identification of ( S )-2-Phenyl- N -(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant K v 7.2 Channel Inhibitor

Cheung, Yiu-Yin, Yu, Haibo, Xu, Kaiping, Zou, Beiyan, Wu, Meng, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 470 KB

english, 2012

22

Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils

Chuah, C., Jones, M. K., Burke, M. L., Owen, H. C., Anthony, B. J., McManus, D. P., Ramm, G. A., Gobert, G. N.

Journal:

Journal of Leukocyte Biology

Year:

2013

Language:

english

File:

PDF, 6.88 MB

english, 2013

23

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay

Storaska, Andrew J., Mei, Jian P., Wu, Meng, Li, Min, Wade, Susan M., Blazer, Levi L., Sjögren, Benita, Hopkins, Corey R., Lindsley, Craig W., Lin, Zhihong, Babcock, Joseph J., McManus, Owen B., Neubi

Journal:

Cellular Signalling

Year:

2013

Language:

english

File:

PDF, 934 KB

english, 2013

24

Maxikdiol: a novel dihydroxyisoprimane as an agonist of Maxi-K channels

Singh, Sheo B., Goetz, Michael A., Zink, Deborah L., Dombrowski, Anne W., Polishook, Jon D., Garcia, Maria L., Schmalhofer, William, McManus, Owen B., Kaczorowski, Gregory J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1994

Language:

english

File:

PDF, 507 KB

english, 1994

25

HTS assays for developing the molecular pharmacology of ion channels

McManus, Owen B

Journal:

Current Opinion in Pharmacology

Year:

2014

Language:

english

File:

PDF, 468 KB

english, 2014

26

Selective Inhibition of the K ir 2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological Characterization of ML133

Wang, Hao-Ran, Wu, Meng, Yu, Haibo, Long, Shunyou, Stevens, Amy, Engers, Darren W., Sackin, Henry, Daniels, J. Scott, Dawson, Eric S., Hopkins, Corey R., Lindsley, Craig W., Li, Min, McManus, Owen B.

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 3.64 MB

english, 2011

27

Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle

Giangiacomo, Kathleen M., Garcia, Maria L., McManus, Owen B.

Journal:

Year:

1992

Language:

english

File:

PDF, 2.08 MB

english, 1992

28

Defining a pro-inflammatory neutrophil phenotype in response to schistosome eggs

Chuah, Candy, Jones, Malcolm K., Burke, Melissa L., McManus, Donald P., Owen, Helen C., Gobert, Geoffrey N.

Journal:

Cellular Microbiology

Year:

2014

Language:

english

File:

PDF, 819 KB

english, 2014

29

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Yu, Haibo, Wu, Meng, Townsend, Steven D., Zou, Beiyan, Long, Shunyou, Daniels, J. Scott, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

30

A High-Throughput Assay for Evaluating State Dependence and Subtype Selectivity of Cav2 Calcium Channel Inhibitors

Dai, Ge, Haedo, Rodolfo J., Warren, Vivien A., Ratliff, Kevin S., Bugianesi, Randal M., Rush, Alison, Williams, Mark E., Herrington, James, Smith, McHardy M., McManus, Owen B., Swensen, Andrew M.

Journal:

Assay and Drug Development Technologies

Year:

2008

Language:

english

File:

PDF, 1.18 MB

english, 2008

31

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Flaherty, Daniel P., Simpson, Denise S., Miller, Melissa, Maki, Brooks E., Zou, Beiyan, Shi, Jie, Wu, Meng, McManus, Owen B., Aubé, Jeffrey, Li, Min, Golden, Jennifer E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 484 KB

english, 2014

32

Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle

Giangiacomo, Kathleen M., Garcia-Calvo, Margarita, Knaus, Hans-Gunther, Mullmann, Theodore J., Garcia, Maria L., McManus, Owen

Journal:

Year:

1995

Language:

english

File:

PDF, 2.53 MB

english, 1995

33

Using life cycle assessment to measure the environmental performance of catalysts and directing research in the conversion of CO2 into commodity chemicals: a look at the potential for fuels from ‘thin-air’

Griffiths, O. Glyn, Owen, Rhodri E., O'Byrne, Justin P., Mattia, Davida, Jones, Matthew D., McManus, Marcelle C.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

34

[IEEE SOUTHEASTCON 2010 - Concord, NC, USA (2010.03.18-2010.03.21)] Proceedings of the IEEE SoutheastCon 2010 (SoutheastCon) - The effects of limited lifetime pseudonyms on certificate revocation list size in VANETS

Nowatkowski, Michael E., Wolfgang, Jennie E., McManus, Chris, Owen, Henry L.

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

35

A Cell-Sparing Electric Field Stimulation Technique for High-Throughput Screening of Voltage-Gated Ion Channels

Bugianesi, Randal M., Augustine, Paul R., Azer, Karim, Dufresne, Claude, Herrington, James, Kath, Gary S., McManus, Owen B., Napolitano, Christopher S., Rush, Alison, Sachs, Jeff, Simpson, Neal, Wisme

Journal:

Assay and Drug Development Technologies

Year:

2006

Language:

english

File:

PDF, 568 KB

english, 2006

36

Profiling Diverse Compounds by Flux- and Electrophysiology-Based Primary Screens for Inhibition of Human Ether-à-go-go Related Gene Potassium Channels

Zou, Beiyan, Yu, Haibo, Babcock, Joseph J., Chanda, Pritam, Bader, Joel S., McManus, Owen B., Li, Min

Journal:

Assay and Drug Development Technologies

Year:

2010

Language:

english

File:

PDF, 784 KB

english, 2010

37

An Automated Electrophysiology Serum Shift Assay for K V Channels

Ratliff, Kevin S., Petrov, Aleksandr, Eiermann, George J., Deng, Qiaolin, Green, Mitchell D., Kaczorowski, Gregory J., McManus, Owen B., Herrington, James

Journal:

Assay and Drug Development Technologies

Year:

2008

Language:

english

File:

PDF, 478 KB

english, 2008

38

Analysis of reports of human exposure to Micotil 300 (tilmicosin injection)

Veenhuizen, Melissa F., Wright, Theressa J., McManus, Robert F., Owens, Jane G.

Journal:

Journal of the American Veterinary Medical Association

Year:

2006

Language:

english

File:

PDF, 318 KB

english, 2006

39

Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter

Ennis, Elizabeth A., Wright, Jane, Retzlaff, Cassandra L., McManus, Owen B., Lin, Zhinong, Huang, Xiaofang, Wu, Meng, Li, Min, Daniels, J. Scott, Lindsley, Craig W., Hopkins, Corey R., Blakely, Randy

Journal:

ACS Chemical Neuroscience

Year:

2015

Language:

english

File:

PDF, 2.60 MB

english, 2015

40

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

Zhu, Yingmin, Lu, Yungang, Qu, Chunrong, Miller, Melissa, Tian, Jinbin, Thakur, Dhananjay P, Zhu, Jinmei, Deng, Zixin, Hu, Xianming, Wu, Meng, McManus, Owen B, Li, Min, Hong, Xuechuan, Zhu, Michael X,

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 2.25 MB

english, 2015

41

Discovery and Characterization of 2-(Cyclopropanesulfonamido)- N -(2-ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1

Wen, Wandong, Wang, Yan, Li, Zhe, Tseng, Pang-Yen, McManus, Owen B., Wu, Meng, Li, Min, Lindsley, Craig W., Dong, Xinzhong, Hopkins, Corey R.

Journal:

Year:

2015

Language:

english

File:

PDF, 424 KB

english, 2015

42

Measuring Neurite Dynamics In Vitro

B. McManus, Owen, McEwen, Dyke

Journal:

Genetic Engineering & Biotechnology News

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

43

Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica

Chuah, Candy, Jones, Malcolm K., McManus, Donald P., Nawaratna, Sujeevi K., Burke, Melissa L., Owen, Helen C., Ramm, Grant A., Gobert, Geoffrey N.

Journal:

International Journal for Parasitology

Year:

2016

Language:

english

File:

PDF, 5.74 MB

english, 2016

44

Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection

AGHAZADEH, MAHDIS, HARVIE, MARINA C., OWEN, HELEN C., VERÍSSIMO, CAROLINA, ALAND, KIERAN V., REID, SIMON A., TRAUB, REBECCA J., McMANUS, DONALD P., McCARTHY, JAMES S., JONES, MALCOLM K.

Journal:

Year:

2016

Language:

english

File:

PDF, 701 KB

english, 2016

45

Characterization of hERG Channel Modulators in Optically Paced Human iPSC-Derived Cardiomyocytes Using Ultra-widefield Optopatch

Hecht, Vivian, Ferrante, John, Atwater, Nicholas, Werley, Kit, McManus, Owen, Urban, Laszlo, Dempsey, Graham

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 57 KB

english, 2017

46

Playgroups as a setting for nutrition and physical activity interventions for mothers with young children: exploratory qualitative findings

Jones, Carlie, Burns, Sharyn, Howat, Peter, Jancey, Jonine, McManus, Alexandra, Carter, Owen

Journal:

Health Promotion Journal of Australia

Year:

2010

Language:

english

File:

PDF, 102 KB

english, 2010

47

Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na V 1.7 Inhibitors

Zhang, Hongkang, Moyer, Bryan D., Yu, Violeta, McGivern, Joseph G., Jarosh, Michael, Werley, Christopher A., Hecht, Vivian C., Babcock, Ryan J., Dong, Kevin, Dempsey, Graham T., McManus, Owen B., Hemp

Journal:

Year:

2020

File:

PDF, 2.68 MB

2020

48

An All-Optical Electrophysiology Screening Platform to Identify Nav Channel Modulators as Pain Therapeutics

Zhang, Hongkang, Werley, Kit, Liu, Pin, Borja, Gabriel, Nagle, Steven, Dempsey, Graham, McManus, Owen

Journal:

Biophysical Journal

Year:

2020

File:

PDF, 52 KB

2020

49

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] D30. NOVEL INSIGHTS INTO CHRONIC LUNG DISEASE AND PULMONARY HYPERTENSION: LATE BREAKING ABSTRACTS - ADAM 15 Protects The Lung From Cigarette Smoke-Induced Lung Inflammation And Pulmonary Emphysema In Mice

Nakajima, Takahiro, McManus, Donna, Tesfaigzi, Yohannes, McDonald, Jacob D., Owen, Caroline A.

Year:

2011

File:

PDF, 19 KB

2011

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